The anticonvulsant and antioxidant activity was examined against Maximum Electro Shock (45 mA for 0.2 sec) and Pentylenetetrazole (65 mg/kg i.p) induced convulsion in Swiss Albino Mice. Mice of either sex weighing 28 -30 g were pretreated with methanolic extract of Lagenaria siceraria (MELS) for 7 days. Convulsion was induced on 8th day and convulsive parameters of both the models were measured. After that, animals were sacrificed by cervical dislocation, brain was removed for biochemical estimations like lipid peroxidation, glutathione in both the experimental model and brain GABA content in MES induced convulsion. Sleep potentiation activity of MELS was undertaken by using Diazepam (6 mg/kg i.p) for induction of sleep. Induction of convulsion caused significant depletion in, Glutathione (GSH), GABA and significant increase in Malondialdehyde (MDA). MELS (400 mg/kg p.o) showed significant reduction in the duration of HLTE (p< 0.001) in and reduced mortality to 33.33% in MES induced convulsion and also exhibited significant (p < 0.05) reduction in duration in PTZ-induced seizures and reduced mortality to 36.33% respectively. MELS (400 mg/kg p.o) showed significant reduction in MDA and increase in GSH in both the experimental model. Whereas level of GABA was in significantly increased in MES induced convulsion. MELS (25 and 50 mg/kg b.w; i.p.) did not show significant effect on diazepam (6 mg/kg b.w; i.p.) induced sleeping time. The data obtained from the study indicates the anticonvulsant potential of MELS in both the experimental model used.
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